How fast will gene sequencing and synthesis technologies progress? What will be the future cost of gene sequencing and genome synthesis? What will be the most attractive and profitable applications? How could a successful open-source synthetic biology movement affect the future of the biotechnology industry? What does it mean to be able to "design" genomes from scratch? How will primary sectors of the economy -- energy, agriculture, chemicals, and pharmaceuticals -- be affected by the emergence of a genomic design discipline? What are some of the most significant biosecurity risks and how can they best be managed?